More on Low CSF 5-MTHF

This article is interesting, for a number of reasons:

http://www.ncbi.nlm.nih.gov/pubmed/3783183?dopt=Abstract

One thing that's really interesting is that the person had a reticulocyte response to thiamine and cobalamin, and that sort of confounds any attempt to attribute something specifically to thiamine. But it sounded like the neurological symptoms were similar to Wernicke's encephalopathy. Also, that article and some of the ones on cerebral folate deficiency suggest to me that neurological involvement may not be uncommon in response to depletion of 5-MTHF from the brain. I know there's only so much one can do with reduced folates, but my interest has to do with wanting to learn what the mechanisms by which folic acid or reduced folates would produce neuroprotection. I'll have to look at more of these articles on cerebral folate deficiency. Here's one of them (http://scholar.google.com/scholar?num=100&hl=en&lr=&q=%22cerebral+folate%22+deficiency+OR+depletion or http://scholar.google.com/scholar?num=100&hl=en&lr=&q=%22cerebrospinal+fluid%22+methyltetrahydrofolate+deficiency+OR+depletion&btnG=Search):

http://www.biopku.org/pdf/blau_hansen.pdf (Hansen et al. pubmed: http://www.ncbi.nlm.nih.gov/pubmed/15781200)

Some of them look kind of crazy, admittedly, and chaotic, and one could argue that the person in the above article did not really have some specific depletion of CSF MTHF but was just benefiting in some sort of nonspecific way from it. But I don't think that's the case.