Potential Involvement of Neural Progenitor Cells in Neurotrophic Effects of Guanosine

There's some evidence that guanosine, for example, given at remarkably-low dosages, intraperitoneally, can promote remyelination by enhancing the proliferation or survival or differentiation, etc., of oligodendrocyte progenitor cells [Jiang et al., 2003: (http://www.ncbi.nlm.nih.gov/pubmed/14663211)]. Some of those types of trophic effects of exogenous purines might work together with something like reduced folates and enhance the differentiation of progenitor cells into glia or neurons.