Glucose Transport and Tau Hyperphosphorylation

This is an interesting article that shows that a reduction in glucose transport, by the GLUT1 and GLUT3 glucose transporters, leads to an increase in tau hyperphosphorylation that is secondary to a reduction in the O-glycosylation of serine and threonine residues on the tau protein:

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2247364 (Liu et al., 2008)
http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=2247364&blobtype=pdf

The authors also found that hypoxia-inducible factor-1alpha (HIF-1alpha) had been reduced, and the authors suggested this reduction may have led to the downregulation of GLUT1 and GLUT3 in the brains of people with Alzheimer's. I wonder if the decreases in HIF-1alpha might have been partially the result of increases in nitric oxide and peroxynitrite in the brains of people with Alzheimer's disease, given that the normal regulation of HIF-1alpha can be disrupted by nitrosative stress.