This article shows that acetaldehyde, a major metabolite of ethanol that can accumulate and contribute to "hangovers," or so the conventional wisdom says, can activate the pyruvate dehydrogenase (PDH) complex and increase the PDH-mediated CO2 output by twofold to threefold. That might be a mechanism whereby ethanol could increase thiamine (vitamin B1) turnover (thiamine diphosphate is a cofactor, along with magnesium, for the E1 component of the PDH complex).
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1163816 (Walsh et al., 1976)
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