Mitochondrial Injury in the Liver and Elsewhere

This is a great article on the role that mitochondrial impairment and damage and mitochondrially-mediated apoptosis play in drug-induced liver damage. The discussion of some of the mechanisms, though, is relevant to understanding mitochondrial damage in neurodegenerative diseases. The author gets at the way research on mitochondrial functioning has been really neglected until fairly recently:

http://www.ncbi.nlm.nih.gov/pubmed/16889760

There's a long section on the mechanisms of toxicity by N-acetyl-para-benzoquinoneimine (NAPQI). I remember an interesting property of some drugs that cause mitochondrial uncoupling is that they're weak bases, and that property can somehow abolish the proton gradient across the mitochondrial membrane. I guess it stands to reason, but I forget the details.