This is one article (Tzu-Hsiu Chen et al.) showing memory-enhancing effects from dietary nucleotides. The first one is in mice and uses a mixture of nucleotides (NT's) at 0.5 % of the diet, meaning 5 g NT's/kg diet:
http://www.ncbi.nlm.nih.gov/pubmed/8937510
Here are the converted dosages (using my conversion factors: http://hardcorephysiologyfun.blogspot.com/2008/12/equations-for-animal-food-intake-and.html):
(23 g inosine/100 g NT's) x (5 g NT's mixture/1 kg diet) x (1,000 mg inosine/1 g inosine) x (0.150 kg diet consumed/kg bw mouse) = 172.5 mg inosine/kg bw/d
(35 g guanosine 5'-monophosphate disodium) x (50) x (0.150) = 262.5 mg GMP Na2/kg bw/d
(21 g cytidine) x (50) x (0.150) = 157.5 mg cytidine/kg bw/d
120 mg uridine/kg bw/d
37.5 mg thymidine/kg/d
If I use the first scaling factor (5.79), to scale it crudely to humans (I'm using the 70 kg figure, because I already used it):
29.8 mg/kg inosine (2,086 mg/d)
45.3 mg/kg GMP Na2 (3,171 mg/d)
27.2 mg/kg cytidine (1,971 mg/d)
20.7 mg/kg uridine (1,441 mg/d)
6.5 mg/kg thymidine (455 mg/d)
I need a new scaling factor for mice, I think, because the purine dosages are really too high. That would probably cause hyperuricemia in humans. I think the limit of total purines (from IMP, AMP or ATP, and GMP combined) would be like 3 grams or 4 maybe, because guanosine and inosine have been shown to elevate uric acid substantially in humans. The pyrimidine dosages are not unreasonable at all. Anyway, I'm not suggesting anyone apply this, but I'm trying to get a sense of what types of dosages produced effects in animals.
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