Here's an interesting article that shows that Icmt knockout mice, mutant mice engineered to have no functional isoprenylcysteine carboxyl methyltransferase (ICMT) enzymes, die during embryonic development. One could say that this only shows the importance of ICMT during development, but, when it's viewed alongside all the other research on ICMT in relation to endothelial cells, it also suggests that ICMT activity just has pretty significant effects in lots of different cell types (during both development and adulthood):
http://www.jbc.org/cgi/content/full/276/8/5841
(pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11121396?dopt=Abstract)
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