Inverse Correlation of Homocysteine With Platelet Count

I just came across this abstract, and I remember seeing it. I haven't read it yet, but it looks interesting:

http://www.ncbi.nlm.nih.gov/pubmed/16011963

The abstract says that, in this group of people the researchers studied, homocysteine levels correlated inversely with the platelet counts of the people and correlated positively with markers of the activation of endothelial cells and platelets. The abstract would imply that the platelet count would be higher upon a reduction in plasma total homocysteine, such as with a reduced folate, but would be, ideally, accompanied by decreases in platelet reactivity and endothelial cell activation/inflammation. This wouldn't necessarily happen, and reducing a disease marker doesn't necessarily fix the disease process that the markers are associated with. There's also the fact that, in a person who has various kinds of autoimmune or inflammatory or prothrombotic disease states, an increase in the platelet count or in lymphocyte proliferation, in response to something like a reduced folate, could exacerbate the condition or negate the effectiveness of a treatment.