Tuesday, December 30, 2008

Mechanism of Magnesium-Induced Inhibition of Acetylcholine Release

The thing I was getting at is that the known inhibitory effect of high levels of Mg2+ on neuromuscular acetylcholine (ACh) release could be secondary to its NMDA receptor antagonism. That inhibition of ACh release, by NMDA receptor antagonism in response to Mg2+, has been shown to occur in the striatum:

http://www.ncbi.nlm.nih.gov/pubmed/7908945?dopt=Abstract

I can't immediately find an article talking about the mechanism in relation to the potentiation of neuromuscular blocking drugs, but I'll bet it's something similar. My point is that magnesium is supposedly not a direct anticholinergic but is thought to block ACh release presynaptically, probably by decreasing calcium influx (such as by NMDA receptor antagonism or calcium channel blockade) into the motor neurons.

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