Solubility and Bioavailability Issues With Uridine, etc.

I was going to mention that the relative bioavailability of free uridine is almost certainly not as low as that article (the one I cited in the last posting) seems to suggest. Uridine is insoluble at concentrations above 10 mM, and I had to find some obscure article on plants or something to find any data on its solubility. I know the solubility of uridine monophosphate disodium is substantially higher (and so is the solubility of uridine diphosphoglucose), but I can't find quantitative solubility data on those uridine derivatives. The way you can tell is that the osmotic GI effects reported in the literature are a result of low solubility, almost certainly. The absence of reports of those issues from human studies using oral uridine diphosphoglucose or the uridine monophosphate disodium strongly implies, as other authors have intimated, that they are substantially more soluble. There's no quantitative solubility data on uridine salts in the Merck Index or online. But there's obviously no solubility issue with triacetyluridine, to any significant degree, in my opinion. But that issue would skew data on relative bioavailability, above a certain concentration, because there would be a plateau of bioavailability of oral uridine, past a certain dosage. Also, some of these ridiculous reports of strange reactions, in rodents, to i.v. uridine are, in my opinion, obviously explainable either in terms of the vehicles used in i.v. preparations (there are countless examples of this in the literature) or in terms of the precipitation of some of the uridine, potentially. Maybe if they'd actually collected solubility data, they wouldn't have botched that sort of thing.

Think about the fact that there's no quantiative solubility data on uridine salts. I looked online for maybe 45 minutes. I could not find any. That's pathetic. It's shocking and shameful, with all of this big public-relations "stuff" about sequencing the human genome and about genes and gene expression and all of that. It's just one example of the deep, deep problems in a lot of these areas. Uridine and its prodrugs are not cure-all's or anything and are only useful up to a point, but think of the wasted money and time in relation to the subjects I've discussed in the last postings. They could have provided much more help than they did to all of those people with brain injuries and degeneration, just by actually exploring the relationship between the therapeutic effects and the increases in plasma uridine (from CDP-choline or a soluble uridine salt or a uridine pro"drug"). It's like hearing about someone living in a big, lavish mansion who's passed out on i.v. opiates or something, all the time, drunk on the hopes of big interventions that never seem to materialize or live up to the empty promises and hype, and who can't care for his or her kids, who are sitting in the corner starving to death (while there are servants running all over the place and tending to the passed-out person's every need). I know these are harsh statements, but this is just disgusting. Every time I start writing or talking about it, I can hardly contain my disgust.