Monday, September 7, 2009

Fractionation of Fixed-Dosage Preparations of Uridine or Triacetyluridine

The context for this posting has to do with the fact that, with some preparations of uridine or triacetyluridine (http://hardcorephysiologyfun.blogspot.com/2009/07/triacetyluridine-uridine-prodrug.html), one is faced with a choice of taking a fixed dosage form intermittently, such as every third day or whatever, taking the whole dosage form daily at a significant cost, or thinking of some way to "fractionate" or parcel out the fixed dosage form of "tang-like" powder. One approach, apart from the freezing of the dosage form dispersed in the liquid, as discussed in that past posting, would be to figure out the approximate "volume," meaning X number of 1/2 teaspoons or X teaspoons or whatever, of the entire dosage form, take so-and-so many 1/2 teaspoons or whatever (so-and-so many "mL" of it), and then just freeze the dry powder in some plastic container. These things might seem strange, but storing it in a plastic bag at room temperature could conceivably allow for bacterial growth, in my opinion, and the condensation formed by the cooling of the air, in a refrigerator, would presumably be greater than that formed in a freezer. I don't know what the best way to do it would be. That way, at least one wouldn't need to worry about intramolecular degradative reactions or oxidative degradation, etc. Anyway, don't shoot the messenger. It's not my fault that it's come down to "tupperware psychopharmacology."

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