Note on Triacetyluridine and Uridine Prodrugs

I was going to mention that triacetyluridine, as discussed in a couple of recent postings, is not only being sold on that obscure website. If one searches on "google shopping," for example, one sees it for sale there. Some of the preparations, however, are sold at either 100 or 200 times the price that triacetyluridine is sold for on that obscure website that I linked to in a posting last winter. I forget the precise difference, but I did a quick calculation on it, when I did the posting in the winter. The company that anyone can look up the name of and that had been researching triacetyluridine has apparently moved on to the testing of RG2417, another uridine prodrug. I'm almost certain that it's just some other acyluridine, but the company is literally not revealing the identity of the compound. I can't find it online. The authors of this article [Tochigi et al., 2008: (http://www.ncbi.nlm.nih.gov/pubmed/18068248)] said, in 2008, that "A large-scale clinical trial of uridine (RG2417) for bipolar depression is underway" (Tochigi et al., 2008, p. 189). It's a uridine prodrug and is probably one of those more lipophilic acyluridines. That would be my guess. The description of it as an "intracellular mood stabilizer" (http://www.marketresearch.com/map/prod/1344386.html) implies that it may be more lipophilic than uridine or triacetyluridine and that it enters cells more readily (i.e. because it's more lipophilic, presumably to enhance entry into the brain). That's just my guess, though, my opinion. I'm not sure what an "extracellular mood stabilizer" would be--I guess one that doesn't actually enter cells. Triacetyluridine is or was designated RG2133 and was also named PN401, because a different company had previously owned the patents or been researching it. Maybe the secrecy is because of all of the controversy that occurred when PN401 (triacetyluridine) was first being researched in mitochondrial disorders. The people who had mitochondrial disorders really wanted PN401 and wanted it to be researched more, and there was just a mess with it. I think the people who wanted it knew, on some level, that it was so close to being identical to uridine itself that....well, I shouldn't talk about all of these issues anymore.